Carbamylation reduces the capacity of IgG for hexamerization and complement activation
نویسندگان
چکیده
منابع مشابه
Carbamylation of immunoglobulin abrogates activation of the classical complement pathway
Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase-dependent cyanate (CNO-) formation. We analyzed the pattern of human IgG1 carbamylation under inflammatory conditions and the effects that this ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2020
ISSN: 0009-9104,1365-2249
DOI: 10.1111/cei.13411